[HTML][HTML] Targeting autophagy-related protein kinases for potential therapeutic purpose
H **ang, J Zhang, C Lin, L Zhang, B Liu… - … Pharmaceutica Sinica B, 2020 - Elsevier
Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …
organelles mediated by lysosomes, plays a significant role in the quality control of …
LRRK2 links genetic and sporadic Parkinson's disease
The past two decades in research has revealed the importance of leucine-rich repeat kinase
2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families …
2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families …
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
DC Berwick, GR Heaton, S Azeggagh… - Molecular …, 2019 - Springer
Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …
[HTML][HTML] Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease
K Zhang, S Zhu, J Li, T Jiang, L Feng, J Pei… - … Pharmaceutica Sinica B, 2021 - Elsevier
Abstract Parkinson's disease (PD), known as one of the most universal neurodegenerative
diseases, is a serious threat to the health of the elderly. The current treatment has been …
diseases, is a serious threat to the health of the elderly. The current treatment has been …
LRRK2 regulation of immune-pathways and inflammatory disease
Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
Mutations in the LRRK2 gene represent the most common genetic cause of late onset
Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully …
Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully …
LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease
F Bonello, SM Hassoun, F Mouton-Liger… - Human Molecular …, 2019 - academic.oup.com
Mutations of LRRK2, encoding leucine-rich repeat kinase 2 (LRRK2), are the leading cause
of autosomal dominant Parkinson's disease (PD). The most frequent of these mutations …
of autosomal dominant Parkinson's disease (PD). The most frequent of these mutations …
Role of the endolysosomal system in Parkinson's disease
DJ Vidyadhara, JE Lee… - Journal of …, 2019 - Wiley Online Library
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, affecting
1–1.5% of the total population. While progress has been made in understanding the …
1–1.5% of the total population. While progress has been made in understanding the …
Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: perspectives and limitations
M Fields, A Marcuzzi, A Gonelli, C Celeghini… - International journal of …, 2023 - mdpi.com
Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by
progressive loss of neuronal functions and structures. Despite having different genetic …
progressive loss of neuronal functions and structures. Despite having different genetic …
LRRK2: autophagy and lysosomal activity
M Madureira, N Connor-Robson… - Frontiers in …, 2020 - frontiersin.org
It has been 15 years since the Leucine-rich repeat kinase 2 (LRRK2) gene was identified as
the most common genetic cause for Parkinson's disease (PD). The two most common …
the most common genetic cause for Parkinson's disease (PD). The two most common …