Candida albicans cell-type switching and functional plasticity in the mammalian host

SM Noble, BA Gianetti, JN Witchley - Nature Reviews Microbiology, 2017 - nature.com
Candida albicans is a ubiquitous commensal of the mammalian microbiome and the most
prevalent fungal pathogen of humans. A cell-type transition between yeast and hyphal …

Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal

S Costa-de-Oliveira, AG Rodrigues - Microorganisms, 2020 - mdpi.com
Candida albicans represents the most frequent isolated yeast from bloodstream infections.
Despite the remarkable progress in diagnostic and therapeutic approaches, these infections …

Candida Infections of the Genitourinary Tract

JM Achkar, BC Fries - Clinical microbiology reviews, 2010 - journals.asm.org
All humans are colonized with Candida species, mostly Candida albicans, yet some develop
diseases due to Candida, among which genitourinary manifestations are extremely …

Genetic and phenotypic intra-species variation in Candida albicans

MP Hirakawa, DA Martinez, S Sakthikumar… - Genome …, 2015 - genome.cshlp.org
Candida albicans is a commensal fungus of the human gastrointestinal tract and a prevalent
opportunistic pathogen. To examine diversity within this species, extensive genomic and …

Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism

K Pande, C Chen, SM Noble - Nature genetics, 2013 - nature.com
Abstract Among∼ 5,000,000 fungal species, C. albicans is exceptional in its lifelong
association with humans, either within the gastrointestinal microbiome or as an invasive …

Gene flow contributes to diversification of the major fungal pathogen Candida albicans

J Ropars, C Maufrais, D Diogo… - Nature …, 2018 - nature.com
Elucidating population structure and levels of genetic diversity and recombination is
necessary to understand the evolution and adaptation of species. Candida albicans is the …

Genomic plasticity of the human fungal pathogen Candida albicans

A Selmecki, A Forche, J Berman - Eukaryotic cell, 2010 - journals.asm.org
The genomic plasticity of Candida albicans, a commensal and common opportunistic fungal
pathogen, continues to reveal unexpected surprises. Once thought to be asexual, we now …

Genotypic Evolution of Azole Resistance Mechanisms in Sequential Candida albicans Isolates

A Coste, A Selmecki, A Forche, D Diogo… - Eukaryotic …, 2007 - journals.asm.org
ABSTRACT TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation
of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida …

Molecular Phylogenetics of Candida albicans

FC Odds, ME Bougnoux, DJ Shaw, JM Bain… - Eukaryotic …, 2007 - journals.asm.org
We analyzed data on multilocus sequence ty** (MLST), ABC ty**, mating type-like locus
(MAT) status, and antifungal susceptibility for a panel of 1,391 Candida albicans isolates …

Systematic Phenoty** of a Large-Scale Candida glabrata Deletion Collection Reveals Novel Antifungal Tolerance Genes

T Schwarzmueller, B Ma, E Hiller, F Istel… - PLoS …, 2014 - journals.plos.org
The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis,
causing infections ranging from superficial to life-threatening disseminated disease. The …