Diabetes mellitus is a serious disease affecting about 5% of people worldwide. Diabetes is
characterized by hyperglycemia and impairment in insulin secretion and/or action …

Nearly unlimited supplies of energy-dense foods and technologies that encourage
sedentary behaviour have introduced a new threat to the survival of our species: obesity and …

Textbook of Diabetes Classic textbook providing diabetologists and endocrinologists with
illustrated and clinically focused content on diabetes Now in its sixth edition, the Textbook of …

It is now widely accepted, given the current weight of experimental evidence, that reactive
oxygen species (ROS) contribute to cell and tissue dysfunction and damage caused by …

Sir2 NAD-dependent deacetylases connect transcription, metabolism, and aging. Increasing
the dosage or activity of Sir2 extends life span in yeast, worms, and flies and promotes fat …

Aims/hypothesis Little information is available on the insulin release properties of pancreatic
islets isolated from type 2 diabetic subjects. Since mitochondria represent the site where …

The exquisitely orchestrated adaptive response to stressors that challenge the homeostasis
of the cell and organism involves important changes in mitochondrial function. A complex …

Since it was first realized that biological energy transduction involves oxygen and ATP,
opinions about the amount of ATP made per oxygen consumed have continually evolved …

Maintenance of body temperature is achieved partly by modulating lipolysis by a network of
complex regulatory mechanisms. Lipolysis is an integral part of the glycerolipid/free fatty …

Leucine, a branched-chain amino acid that must be supplied in the daily diet, plays an
important role in controlling protein synthesis and regulating cell metabolism in various cell …