Growth/differentiation factor-15 (GDF-15), also named macrophage inhibitory cytokine-1, is a
divergent member of the transforming growth factor β superfamily. While physiological …

Abstract Growth differentiation factor-15 (GDF-15), a member of the TGF-β superfamily, plays
multiple roles in a wide variety of cellular processes. It is expressed at low levels under …

Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unmet medical need. It is
characterized by formation of scar tissue leading to a progressive and irreversible decline in …

Genistein is one of the main components of soy-based foods, which are widely known for
their many benefits, including anti-cancer, anti-inflammatory, and antioxidant effects. In this …

Glaucoma is the leading cause of irreversible blindness worldwide. Although the etiology of
glaucoma is incompletely understood, it is known that the extracellular matrix (ECM) of the …

Purpose Biophysical and biochemical attributes of the extracellular matrix are major
determinants of cell fate in homeostasis and disease. Ocular hypertension and glaucoma …

High myopia is a risk factor for primary open angle glaucoma (POAG). The pathological
mechanism of high myopia induced POAG occurrence is not fully understood. In this study …

The alveolar bone provides structural support against compressive and tensile forces
generated during mastication as well as during orthodontic treatment. To avoid abnormal …

Glaucoma is characterized by a continuous loss of retinal ganglion cells. The cause of
glaucoma is associated with an increase in intraocular pressure (IOP), but the underlying …

The inflammatory chemokines, monocyte chemoattractant protein (MCP)-1 and IL-8, are
produced by normal trabecular meshwork cells (TM) and elevated in the aqueous humor of …