The nuts and bolts of AGC protein kinases
The AGC kinase subfamily of protein kinases contains 60 members, including PKA, PKG
and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K …
and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K …
Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression
N Isakov - Seminars in cancer biology, 2018 - Elsevier
The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …
members that are critical regulators of numerous cellular functions, including cell cycle and …
[HTML][HTML] Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor
Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the
unambiguous tumor promoting function of their potent ligands, phorbol esters, and the …
unambiguous tumor promoting function of their potent ligands, phorbol esters, and the …
Emerging insights into the molecular and cellular basis of glioblastoma
GP Dunn, ML Rinne, J Wykosky… - Genes & …, 2012 - genesdev.cshlp.org
Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive
multiplatform genomic characterization has provided a higher-resolution picture of the …
multiplatform genomic characterization has provided a higher-resolution picture of the …
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
A Carnero, C Blanco-Aparicio, O Renner… - Current cancer drug …, 2008 - ingentaconnect.com
PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
Structural basis of protein kinase C isoform function
SF Steinberg - Physiological reviews, 2008 - journals.physiology.org
Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …
The PI3K–PDK1 connection: more than just a road to PKB
Phosphoinositide 3-kinases (PI3Ks) generate specific inositol lipids that have been
implicated in the regulation of cell growth, proliferation, survival, differentiation and …
implicated in the regulation of cell growth, proliferation, survival, differentiation and …
[HTML][HTML] Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase
Elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2. Insulin induces
dephosphorylation of eEF2 and inactivation of eEF2 kinase, and these effects are blocked …
dephosphorylation of eEF2 and inactivation of eEF2 kinase, and these effects are blocked …
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif
The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
Serum-and glucocorticoid-inducible kinases (SGKs) form a novel family of serine/threonine
kinases that are activated in response to a variety of extracellular stimuli. SGKs are related to …
kinases that are activated in response to a variety of extracellular stimuli. SGKs are related to …