Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …

Organoids form through self-organization processes in which initially homogeneous
populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern …

Recent advances have allowed for three-dimensional (3D) printing technologies to be
applied to biocompatible materials, cells and supporting components, creating a field of 3D …

Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

There has been a growing need for in vitro models of neurodegenerative diseases such as
Alzheimer's disease that would enable a better understanding of etiology and faster …

Recently, there has been growing interest in applying bioprinting techniques to stem cell
research. Several bioprinting methods have been developed utilizing acoustics …

In vitro 3D cancer models that provide a more accurate representation of disease in vivo are
urgently needed to improve our understanding of cancer pathology and to develop better …

We have developed a three-dimensional (3D) liver-on-a-chip to investigate the interaction of
hepatocytes and hepatic stellate cells (HSCs) in which primary 3D hepatocyte spheroids …

An attractive option for tissue engineering is to use of multicellular spheroids as
microtissues, particularly with stem cell spheroids. Conventional approaches of fabricating …

Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …