Neisseria gonorrhoeae host adaptation and pathogenesis

SJ Quillin, HS Seifert - Nature Reviews Microbiology, 2018 - nature.com
The host-adapted human pathogen Neisseria gonorrhoeae is the causative agent of
gonorrhoea. Consistent with its proposed evolution from an ancestral commensal bacterium …

Exploration of the sialic acid world

R Schauer, JP Kamerling - Advances in carbohydrate chemistry and …, 2018 - Elsevier
Sialic acids are cytoprotectors, mainly localized on the surface of cell membranes with
multiple and outstanding cell biological functions. The history of their structural analysis …

Neisseria gonorrhoeae vaccines: a contemporary overview

E Williams, KL Seib, CK Fairley… - Clinical Microbiology …, 2024 - journals.asm.org
Neisseria gonorrhoeae infection is an important public health issue, with an annual global
incidence of 87 million. N. gonorrhoeae infection causes significant morbidity and can have …

Multifarious roles of sialic acids in immunity

A Varki, P Gagneux - Annals of the New York Academy of …, 2012 - Wiley Online Library
Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

Long-circulating and target-specific nanoparticles: theory to practice

SM Moghimi, AC Hunter, JC Murray - Pharmacological reviews, 2001 - Elsevier
The rapid recognition of intravenously injected colloidal carriers, such as liposomes and
polymeric nanospheres from the blood by Kupffer cells, has initiated a surge of development …

Chemical diversity in the sialic acids and related α-keto acids: an evolutionary perspective

T Angata, A Varki - Chemical reviews, 2002 - ACS Publications
The glycan chains of vertebrate glycoconjugates are composed mostly of five-and six-
carbon sugars. One striking exception is the family of sialic acids (Sia), which are R-keto …

Advances in the biology and chemistry of sialic acids

X Chen, A Varki - ACS chemical biology, 2010 - ACS Publications
Sialic acids are a subset of nonulosonic acids, which are nine-carbon α-keto aldonic acids.
Natural existing sialic acid-containing structures are presented in different sialic acid forms …

Complement control protein factor H: the good, the bad, and the inadequate

VP Ferreira, MK Pangburn, C Cortés - Molecular immunology, 2010 - Elsevier
The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …

Structural basis for sialic acid–mediated self-recognition by complement factor H

BS Blaum, JP Hannan, AP Herbert, D Kavanagh… - Nature chemical …, 2015 - nature.com
The serum protein complement factor H (FH) ensures downregulation of the complement
alternative pathway, a branch of innate immunity, upon interaction with specific glycans on …

Sialic acid utilization by bacterial pathogens

E Severi, DW Hood, GH Thomas - Microbiology, 2007 - microbiologyresearch.org
Sialic acid occupies the terminal position within glycan molecules on the surfaces of many
vertebrate cells, where it functions in diverse cellular processes such as intercellular …