Despite advances in our understanding of the pathophysiology of many cardiovascular
diseases (CVDs) and expansion of available therapies, the global burden of CVD …

The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is
increasing worldwide. This triad of disorders is associated with considerable morbidity and …

Atherosclerosis, chronic non-communicable diseases, and metabolic syndrome are highly
interconnected and collectively contribute to global health concerns that reduce life …

Dental caries, a highly prevalent oral disease, impacts a significant portion of the global
population. Conventional approaches that indiscriminately eradicate microbes disrupt the …

For millions of years, our resident microbes have coevolved and coexisted with us in a
mostly harmonious symbiotic relationship. We are not distinct entities from our microbiome …

The human mouth harbors a complex microbiota, the composition of which is potentially
influenced by a wide range of factors, including the intake of food and drink, the availability …

Dental diseases are now viewed as a consequence of a deleterious shift in the balance of
the normally stable resident oral microbiome. It is known that frequent carbohydrate …

Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic
signaling molecule involved in cardiovascular and metabolic regulation. More recently, an …

Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …