[HTML][HTML] The role of copper homeostasis in brain disease

Y An, S Li, X Huang, X Chen, H Shan… - International journal of …, 2022 - mdpi.com
In the human body, copper is an important trace element and is a cofactor for several
important enzymes involved in energy production, iron metabolism, neuropeptide activation …

Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …

MG Savelieff, G Nam, J Kang, HJ Lee, M Lee… - Chemical …, 2018 - ACS Publications
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

An artificial light-harvesting system based on the ESIPT–AIE–FRET triple fluorescence mechanism

T **ao, C Bao, L Zhang, K Diao, D Ren… - Journal of Materials …, 2022 - pubs.rsc.org
It is of great significance to combine different fluorescence mechanisms to accurately
regulate the properties of organic fluorescent materials, such as the Stokes shift, emission …

Revolutionizing Alzheimer's treatment: harnessing human serum albumin for targeted drug delivery and therapy advancements

D Shastri, V Raj, S Lee - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder initiated by amyloid-beta (Aβ)
accumulation, leading to impaired cognitive function. Several delivery approaches have …

A turn-off fluorescent probe for the detection of Cu 2+ based on a tetraphenylethylene-functionalized salicylaldehyde Schiff-base

HF **e, CJ Yu, YL Huang, H Xu, QL Zhang… - Materials Chemistry …, 2020 - pubs.rsc.org
A non-planar tetraphenylethylene-functionalized salicylaldehyde Schiff-base fluorescent
probe (TPE-An-Py) with aggregation-induced enhanced emission (AIEE) characteristics was …

Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis

K Li, A Li, Y Mei, J Zhao, Q Zhou, Y Li, M Yang… - Environmental Pollution, 2023 - Elsevier
Alterations in the concentrations of trace elements may play a vital role in Alzheimer
dementia progression. However, previous research results are inconsistent, and there is still …

Advance of sporadic Alzheimer's disease animal models

L Zhang, C Chen, MSH Mak, J Lu, Z Wu… - Medicinal research …, 2020 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disease. In the past decades, numbers of promising drug candidates …

Multi-targetable chalcone analogs to treat deadly Alzheimer's disease: Current view and upcoming advice

X Zhang, KP Rakesh, SNA Bukhari, M Balakrishna… - Bioorganic …, 2018 - Elsevier
The complications of Alzheimer's disease AD were deadly dangerous cause of
neurodegenerative disorders connected with the decline of the cognitive functions and loss …

A Semisynthetic Bioluminescence Sensor for Ratiometric Imaging of Metal Ions In Vivo Using DNAzymes Conjugated to An Engineered Nano‐Luciferase

M **ong, Y Wu, G Kong, W Lewis, Z Yang… - Angewandte …, 2023 - Wiley Online Library
DNA‐based probes have gained significant attention as versatile tools for biochemical
analysis, benefiting from their programmability and biocompatibility. However, most existing …

Recent Advances in Targeting Transition Metals (Copper, Iron, and Zinc) in Alzheimer's Disease

R Singh, A Panghal, K Jadhav, A Thakur… - Molecular …, 2024 - Springer
Abstract Changes in the transition metal homeostasis in the brain are closely linked with
Alzheimer's disease (AD), including intraneuronal iron accumulation and extracellular …