Lipid metabolism and cancer

X Bian, R Liu, Y Meng, D **ng, D Xu, Z Lu - Journal of Experimental …, 2021 - rupress.org
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

[HTML][HTML] Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

D Du, C Liu, M Qin, X Zhang, T **, S Yuan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence
worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat …

[HTML][HTML] Lipid alterations in chronic liver disease and liver cancer

B Paul, M Lewinska, JB Andersen - JHEP reports, 2022 - Elsevier
Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

X Zuo, Z Chen, W Gao, Y Zhang, J Wang… - Journal of hematology & …, 2020 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) possess significant regulatory
functions in multiple biological and pathological processes, especially in cancer …

HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence

J Fu, X Su, Z Li, L Deng, X Liu, X Feng, J Peng - Oncogene, 2021 - nature.com
This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor
(HGF)/mesenchymal–epithelial transition factor (c-MET)) signaling pathway in cancers. First …

The cholesterol pathway: impact on immunity and cancer

RJ King, PK Singh, K Mehla - Trends in immunology, 2022 - cell.com
Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

Targeting SREBP-2-regulated mevalonate metabolism for cancer therapy

L Xue, H Qi, H Zhang, L Ding, Q Huang, D Zhao… - Frontiers in …, 2020 - frontiersin.org
Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …

Recent advances in analytical strategies for mass spectrometry-based lipidomics

T Xu, C Hu, Q Xuan, G Xu - Analytica chimica acta, 2020 - Elsevier
Lipids are vital biological molecules and play multiple roles in cellular function of
mammalian organisms such as cellular membrane anchoring, signal transduction, material …

FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis

Q Du, P Liu, C Zhang, T Liu, W Wang, C Shang… - Cell death & …, 2022 - nature.com
Cervical cancer (CC) patients with lymph node metastasis (LNM) have a poor prognosis.
Clarification of the detailed mechanisms underlying LNM may provide potential clinical …

Gut flora disequilibrium promotes the initiation of liver cancer by modulating tryptophan metabolism and up-regulating SREBP2

W Chen, L Wen, Y Bao, Z Tang… - Proceedings of the …, 2022 - National Acad Sciences
The gut microbiota and liver cancer have a complex interaction. However, the role of gut
microbiome in liver tumor initiation remains unknown. Herein, liver cancer was induced …