Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Both intrinsic cell state changes and variations in the composition of stem cell populations
have been implicated as contributors to aging. We used single-cell RNA-seq to dissect …

The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …

Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

The effects of aging on the immune system are manifest at multiple levels that include
reduced production of B and T cells in bone marrow and thymus and diminished function of …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …

Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …