Information decomposition and the informational architecture of the brain

AI Luppi, FE Rosas, PAM Mediano, DK Menon… - Trends in Cognitive …, 2024 - cell.com
To explain how the brain orchestrates information-processing for cognition, we must
understand information itself. Importantly, information is not a monolithic entity. Information …

[HTML][HTML] The strength of weak integrated information theory

PAM Mediano, FE Rosas, D Bor, AK Seth… - Trends in Cognitive …, 2022 - cell.com
The integrated information theory of consciousness (IIT) is divisive: while some believe it
provides an unprecedentedly powerful approach to address the 'hard problem', others …

[HTML][HTML] Genuine high-order interactions in brain networks and neurodegeneration

R Herzog, FE Rosas, R Whelan, S Fittipaldi… - Neurobiology of …, 2022 - Elsevier
Brain functional networks have been traditionally studied considering only interactions
between pairs of regions, neglecting the richer information encoded in higher orders of …

Partial entropy decomposition reveals higher-order information structures in human brain activity

TF Varley, M Pope, Maria Grazia… - Proceedings of the …, 2023 - National Acad Sciences
The standard approach to modeling the human brain as a complex system is with a network,
where the basic unit of interaction is a pairwise link between two brain regions. While …

Multivariate information theory uncovers synergistic subsystems of the human cerebral cortex

TF Varley, M Pope, J Faskowitz, O Sporns - Communications biology, 2023 - nature.com
One of the most well-established tools for modeling the brain is the functional connectivity
network, which is constructed from pairs of interacting brain regions. While powerful, the …

Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies

AI Luppi, SP Singleton, JY Hansen… - Nature Biomedical …, 2024 - nature.com
The mechanisms linking the brain's network structure to cognitively relevant activation
patterns remain largely unknown. Here, by leveraging principles of network control, we show …

Greater than the parts: a review of the information decomposition approach to causal emergence

PAM Mediano, FE Rosas, AI Luppi… - … of the Royal …, 2022 - royalsocietypublishing.org
Emergence is a profound subject that straddles many scientific disciplines, including the
formation of galaxies and how consciousness arises from the collective activity of neurons …

Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain

AI Luppi, L Uhrig, J Tasserie, CM Signorelli… - Nature …, 2024 - nature.com
A central challenge of neuroscience is to elucidate how brain function supports
consciousness. Here, we combine the specificity of focal deep brain stimulation with fMRI …

Mechanisms underlying disorders of consciousness: bridging gaps to move toward an integrated translational science

AI Luppi, J Cain, LRB Spindler, UJ Górska, D Toker… - Neurocritical care, 2021 - Springer
Aim In order to successfully detect, classify, prognosticate, and develop targeted therapies
for patients with disorders of consciousness (DOC), it is crucial to improve our mechanistic …

Information-processing dynamics in neural networks of macaque cerebral cortex reflect cognitive state and behavior

TF Varley, O Sporns, S Schaffelhofer… - Proceedings of the …, 2023 - National Acad Sciences
One of the essential functions of biological neural networks is the processing of information.
This includes everything from processing sensory information to perceive the environment …