Growth factors play a crucial role in regulating a broad variety of biological processes and
are regarded as powerful therapeutic agents in tissue engineering and regenerative …

Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing
physical and mental challenges for patients due to the lack of efficient curative therapy …

There is a general increase in the number of patients with non-healing skin wounds,
imposing a huge social and economic burden on patients and healthcare systems. Severe …

Skin wounds accompanied by massive bleeding and bacterial infection can be life-
threatening and pose a significant challenge to clinical wound management. Herein, we …

Silks are a class of proteins generated naturally by different arthropods, including silkworms,
spiders, scorpions, mites, wasps, and bees. This review discusses the silk fibroin and sericin …

Silk sericin is a class of protein biopolymers produced by silkworms. Increasing attention has
been paid to silk sericin for biomedical applications in the last decade, not only because of …

Improving the degree of vascularization through the regulation of wound microenvironment
is crucial for wound repair. Gene activated matrix (GAM) technology provides a new …

Silkworm silk protein fibroin and spider silk spidroin are known biocompatible and natural
biodegradable polymers in biomedical applications. The presence of β-sheets in silk fibroin …

Silk sericin (SS) is a byproduct of the silk production process that consists of 18​ amino
acids and numerous polar groups. SS has a range of unique physical, chemical, and …

The multi-layered skin structure includes the epidermis, dermis and hypodermis, which
forms a sophisticated tissue composed of extracellular matrix (ECM). The wound repair is a …