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Assembly of the mycobacterial cell wall
Mycobacterium tuberculosis remains one of the most successful bacterial pathogens,
claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and …
claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and …
The mycobacterial cell wall—peptidoglycan and arabinogalactan
The mycobacterial bacillus is encompassed by a remarkably elaborate cell wall structure.
The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of …
The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of …
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …
leading cause of death from an infectious disease, with a mortality rate of over a million …
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis
ABSTRACT SQ109, a 1, 2-diamine related to ethambutol, is currently in clinical trials for the
treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that …
treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that …
[HTML][HTML] Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress
Recent data indicate that the nutrients available to Mycobacterium tuberculosis (Mtb) inside
its host cell are restricted in their diversity. Fatty acids and cholesterol appear more favored; …
its host cell are restricted in their diversity. Fatty acids and cholesterol appear more favored; …
Type VII secretion—mycobacteria show the way
Recent evidence shows that mycobacteria have developed novel and specialized secretion
systems for the transport of extracellular proteins across their hydrophobic, and highly …
systems for the transport of extracellular proteins across their hydrophobic, and highly …
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean
Background Mycobacterium tuberculosis is the principal etiologic agent of human
tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its …
tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its …
Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production
Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous
disease states. Despite its importance, the ability to study metabolism at a global scale using …
disease states. Despite its importance, the ability to study metabolism at a global scale using …
Antituberculosis drugs: ten years of research
YL Janin - Bioorganic & medicinal chemistry, 2007 - Elsevier
Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …
Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state
The cell envelope of mycobacteria, which include the causative agents of tuberculosis and
leprosy, is crucial for their success as pathogens. Despite a continued strong emphasis on …
leprosy, is crucial for their success as pathogens. Despite a continued strong emphasis on …