Transcriptional regulation and multiple functions of MAO genes

JC Shih, JB Wu, K Chen - Journal of neural transmission, 2011 - Springer
Monoamine oxidase (MAO) A and MAO B are a crucial pair of isoenzymes, which oxidatively
deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen …

An update on amine oxidase inhibitors: multifaceted drugs

MS Song, D Matveychuk, EM MacKenzie… - Progress in neuro …, 2013 - Elsevier
Although not used as extensively as other antidepressants for the treatment of depression,
the monoamine oxidase (MAO) inhibitors continue to hold a niche in psychiatry and to have …

Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis

JB Wu, C Shao, X Li, Q Li, P Hu, C Shi, Y Li… - The Journal of clinical …, 2014 - jci.org
Tumors from patients with high-grade aggressive prostate cancer (PCa) exhibit increased
expression of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades …

Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs

C Gnerre, M Catto, F Leonetti, P Weber… - Journal of medicinal …, 2000 - ACS Publications
A large series of coumarin derivatives (71 compounds) were tested for their monoamine
oxidase A and B (MAO-A and MAO-B) inhibitory activity. Most of the compounds acted …

Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells

JS Isenberg, JE Klaunig - Toxicological Sciences, 2000 - academic.oup.com
Rotenone inhibits spontaneously and chemically induced hepatic tumorigenesis in rodents
through the induction of apoptosis. However, the mechanism for the induction of apoptosis …

Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway

XM Ou, K Chen, JC Shih - Proceedings of the National Academy of …, 2006 - pnas.org
Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and
produces reactive oxygen that may cause neuronal cell death. We have previously reported …

Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer

R Bharti, G Dey, AK Das, M Mandal - British journal of cancer, 2018 - nature.com
Background Monoamine oxidases (MAO) are mitochondrial enzymes functioning in
oxidative metabolism of monoamines. The action of MAO-A has been typically described in …

Amine oxidases in apoptosis and cancer

A Toninello, P Pietrangeli, U De Marchi, M Salvi… - … et Biophysica Acta (BBA …, 2006 - Elsevier
Amine oxidases, the major enzymes of biogenic amines metabolism, are considered to be
biological regulators, especially for cell growth and differentiation. A primary involvement of …

Regulation of JNK/ERK activation, cell apoptosis, and tissue regeneration by monoamine oxidases after renal ischemia‐reperfusion

OR Kunduzova, P Bianchi, N Pizzinat… - The FASEB …, 2002 - Wiley Online Library
Reactive oxygen species (ROS) contribute to the ischemia‐reperfusion injury. In kidney, the
intracellular sources of ROS during ischemia‐reperfusion are still unclear. In the present …

Monoamine oxidase inhibitors from Gentiana lutea

H Haraguchi, Y Tanaka, A Kabbash, T Fujioka, T Ishizu… - Phytochemistry, 2004 - Elsevier
Three monoamine oxidase (MAO) inhibitors were isolated from Gentiana lutea. Their
structures were elucidated to be 3-3 ″linked-(2′-hydroxy-4-O-isoprenylchalcone)-(2 …