Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

Cancer is the quintessential complex disease. As technologies evolve faster each day, we
are able to quantify the different layers of biological elements that contribute to the …

As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …

N 6-methyladenosine (m6A) is the most abundant internal modification on mammalian
messenger RNA. It is installed by a writer complex and can be reversed by erasers such as …

Chemical modifications of histones can mediate diverse DNA-templated processes,
including gene transcription,–. Here we provide evidence for a class of histone post …

Autophagy is crucial for maintaining cellular energy homeostasis and for cells to adapt to
nutrient deficiency, and nutrient sensors regulating autophagy have been reported …

The adenomatous polyposis coli (APC) is a frequently mutated tumour suppressor gene in
cancers. However, whether APC is regulated at the epitranscriptomic level remains elusive …

Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC
compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but …

Chromatin immunoprecipitation with massively parallel sequencing (ChIP-seq) is widely
used to identify binding sites for a target protein in the genome. An important scientific …

For nearly a century developmental biologists have recognized that cells from embryos can
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …