Neutrophil migration and its role during inflammation has been the focus of increased
interest in the past decade. Advances in live imaging and the use of new model systems …

Neutrophils are the primary cells recruited to inflamed sites during an innate immune
response to tissue damage and/or infection. They are finely sensitive to inciting stimuli to …

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an
essential component of tumour dissemination during progression and metastasis. This …

During random locomotion, human neutrophils and Dictyostelium discoideum amoebae
repeatedly extend and retract cytoplasmic processes. During directed cell migration …

Interactions between B and T cells are essential for most antibody responses, but the
dynamics of these interactions are poorly understood. By two-photon microscopy of intact …

After they are born and differentiate, neurons break their previous symmetry, dramatically
change their shape, and establish two structurally and functionally distinct compartments …

Growth factors play a crucial role in information transfer between cells and their
microenvironment in tissue engineering and regeneration. They initiate their action by …

Although many of the regulators of actin assembly are known, we do not understand how
these components act together to organize cell shape and movement. To address this …

N negative Rac inhibits chemoattractant-stimulated accumulation of actin polymers and
membrane translocation of both fluorescent probes and attainment of morphologic polarity …

Directional migration moves cells rapidly between points, whereas random migration allows
cells to explore their local environments. We describe a Rac1 mechanism for determining …