Following the impressive progress in the treatment of relapsing–remitting multiple sclerosis
(MS), the major challenge ahead is the development of treatments to prevent or delay the …

Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Background Quantitative in vivo imaging of myelin loss and repair in patients with multiple
sclerosis (MS) is essential to understand the pathogenesis of the disease and to evaluate …

Abstract Purpose of Review The purpose of this review is to discuss the interaction between
aging, progressive disease course, disability worsening, and treatment strategies in multiple …

Background Astrocytes play an important role in the growth and survival of develo**
neurons by secreting neurotrophic factors. Objective The goal of this study was to investigate …

Purpose To investigate the neuroprotective effects of low-intensity pulsed (LIP) ultrasound
on memory impairment and central nervous system injury in a rat model of vascular …

An accurate in vivo measure of myelin content is essential to deepen our insight into the
mechanisms underlying demyelinating and dysmyelinating neurological disorders, and to …

Abstract Purpose of Review Multiple sclerosis is characterized by a diverse and complex
pathology. Clinical relapses, the hallmark of the disease, are accompanied by focal white …

Background: There is growing interest in white matter (WM) imaging with positron emission
tomography (PET). Objectives: We studied the association of cognitive function in late …

Background Brain PET imaging with different tracers is mainly clinically used in the field of
neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of …