Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …

Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, demyelinating, and
neurodegenerative disease of the central nervous system (CNS). Immune cell infiltration can …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

Upon antigen recognition, naive T cells undergo rapid expansion and activation. The energy
requirements for this expansion are formidable, and T‐cell activation is accompanied by …

Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

Macrophages and microglia play crucial roles during central nervous system development,
homeostasis and acute events such as infection or injury. The diverse functions of tissue …

Generation and deposition of amyloid beta peptides and neurofibrillary tangle formation are
key mechanisms involved in AD pathogenesis. Recent evidence suggests that inflammatory …

Generation of neurotoxic amyloid β peptides and their deposition along with neurofibrillary
tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Recent …