This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have
identified several genetic loci associated with typical AF. We sought to identify common …

Different calcium signals in the endothelium and smooth muscle target different types of
Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium …

The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to
describe the hypothetical factor responsible for myocyte hyperpolarisations not associated …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

The endothelium, although only a single layer of cells lining the vascular and lymphatic
systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 …

The endothelium controls vascular tone not only by releasing nitric oxide (NO) and
prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth …

Endothelial dysfunction is a major player in the development and progression of vascular
pathology in pulmonary arterial hypertension (PAH), a disease associated with small vessel …

Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …