New generation sequencing is greatly expanding the capacity to examine the composition of
mutant spectra of viral quasispecies in infected cells and host organisms. Here we review …

Current advancements in antiretroviral therapy (ART) have turned HIV-1 infection into a
chronic and manageable disease. However, treatment is only effective until HIV-1 develops …

Increasing evidence indicates that viruses do not simply propagate as independent virions
among cells, organs, and hosts. Instead, viral spread is often mediated by structures that …

Viral quasispecies are distinct but closely related mutants formed by the disparity in viral
genomes due to recombination, mutations, competition, and selection pressure. Theoretical …

The rhizome concept proposed by Gilles Deleuze and Félix Guattari offers a novel
perspective on the organization and interdependence of complex constellations of …

Favipiravir is an antiviral agent effective against several RNA viruses. The drug has been
shown to protect mice against experimental infection with a lethal dose of West Nile virus …

In a screen for ribavirin resistance, a novel high-fidelity variant of human enterovirus 71
(EV71) with the single amino acid change L123F in its RNA-dependent RNA polymerase …

Given the inherent dynamics of a viral quasispecies, we are often interested in the
comparison of diversity indices of sequential samples of a patient, or in the comparison of …

Cell culture-produced hepatitis C virus (HCV) has been subjected to up to 100 serial
passages in human hepatoma cells in the absence or presence of different doses of alpha …

Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under
investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral …