[HTML][HTML] The 2022 World Health Organization classification of tumours of the urinary system and male genital organs—part A: renal, penile, and testicular tumours

H Moch, MB Amin, DM Berney, EM Compérat, AJ Gill… - European urology, 2022 - Elsevier
The fifth edition of the World Health Organization (WHO) classification of urogenital tumours
(WHO “Blue Book”), published in 2022, contains significant revisions. This review …

[HTML][HTML] What's new in the WHO 2022 classification of kidney tumours?

R Alaghehbandan, F Siadat, K Trpkov - Pathologica, 2023 - ncbi.nlm.nih.gov
Summary The World Health Organization (WHO) 2022 classification of urinary and male
genital tumours (5th edition) has significantly improved our understanding of the …

Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases

M Farcaş, Z Gatalica, K Trpkov, J Swensen, M Zhou… - Modern …, 2022 - nature.com
A distinct renal tumor has recently been described as “high-grade oncocytic renal tumor”
and “sporadic renal cell carcinoma with eosinophilic and vacuolated cytoplasm”. The …

TSC/MTOR-associated eosinophilic renal tumors exhibit a heterogeneous clinicopathologic spectrum: a targeted next-generation sequencing and gene expression …

Q **a, X Wang, M Zhao, H He, R Fang… - The American Journal …, 2022 - journals.lww.com
Background: Several TSC1/2-or MTOR-mutated eosinophilic renal tumor subsets are
emerging, including eosinophilic solid and cystic renal cell carcinoma (ESC RCC) …

Low‐grade oncocytic tumour of the kidney is characterised by genetic alterations of TSC1, TSC2, MTOR or PIK3CA and consistent GATA3 positivity

SR Williamson, O Hes, K Trpkov, A Aggarwal… - …, 2023 - Wiley Online Library
Low‐grade oncocytic tumour (LOT) of the kidney has recently emerged as a potential novel
tumour type. Despite similarity to oncocytoma or eosinophilic chromophobe renal cell …

[HTML][HTML] Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney

P Kapur, M Gao, H Zhong, S Chintalapati, M Mitui… - Modern Pathology, 2022 - Elsevier
Low-grade oncocytic tumor (LOT) of the kidney is a recently described entity with poorly
understood pathogenesis. Using next-generation sequencing (NGS) and complementary …

Low-grade oncocytic tumor of kidney (CK7-positive, CD117-negative): incidence in a single institutional experience with clinicopathological and molecular …

O Kravtsov, S Gupta, JC Cheville, WR Sukov… - Human pathology, 2021 - Elsevier
Low-grade oncocytic tumor of the kidney (LOT) is characterized by cytoplasmic eosinophilia
and a CK7-positive/CD117-negative immunophenotype. Morphologically, they exhibit …

[HTML][HTML] Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1

A Morini, T Drossart, MO Timsit, M Sibony, V Vasiliu… - Modern Pathology, 2022 - Elsevier
Low-grade oncocytic renal tumor (LOT) is an emerging provisional entity, described as rare
solid renal oncocytic/eosinophilic tumor sharing diffuse CK7 and negative CD117 …

A pilot radiometabolomics integration study for the characterization of renal oncocytic neoplasia

ME Klontzas, E Koltsakis, G Kalarakis, K Trpkov… - Scientific Reports, 2023 - nature.com
Differentiating benign renal oncocytic tumors and malignant renal cell carcinoma (RCC) on
imaging and histopathology is a critical problem that presents an everyday clinical …

Recent advances in renal tumors with TSC/mTOR pathway abnormalities in patients with tuberous sclerosis complex and in the sporadic setting

P Kapur, J Brugarolas, K Trpkov - Cancers, 2023 - mdpi.com
Simple Summary In the past decade, several novel renal neoplasms characterized by
mutations in the tuberous sclerosis complex (TSC) or mechanistic target of rapamycin …