The Cannabis plant has been used for many of years as a medicinal agent in the relief of
pain and seizures. It contains approximately 540 natural compounds including more than …

Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here,
we describe their molecular architecture, physiological roles, and involvement in genetically …

Epilepsy is the most common neurological disorder, with over 50 million people worldwide
affected. Recent evidence suggests that the transient receptor potential cation channel …

Objectives To describe the antiepileptic drug (AED) treatment of patients with early infantile
epileptic encephalopathy due to KCNQ 2 mutations during the neonatal phase and the first …

Objectives: To determine the frequency of KCNQ2 mutations in patients with neonatal
epileptic encephalopathy (NEE), and to expand the phenotypic spectrum of KCNQ2 epileptic …

Recently, cannabis has been suggested as a potential alternative therapy for refractory
epilepsy, which affects 30% of epilepsy, both adults and children, who do not respond to …

Background KCNQ2 related disorders comprise both benign seizure disorders and early
onset epileptic encephalopathies. Especially within the latter group, patients suffer from …

This article aims to summarize the current views of AED action and the promising new
targets for the pharmacotherapy of epilepsy. In the first section of this paper, a …

Neuronal Kv7 channels represent important pharmacological targets for hyperexcitability
disorders including epilepsy. Retigabine is the prototype Kv7 activator clinically approved for …

Objective Pathogenic variants in KCNT2 are rare causes of developmental epileptic
encephalopathy (DEE). We herein describe the phenotypic and genetic features of patients …