Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …

According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …

Gene regulation involves activation of RNA polymerase II (Pol II) that is paused and bound
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …

For 15 years the mission of PhosphoSitePlus®(PSP, https://www. phosphosite. org) has
been to provide comprehensive information and tools for the study of mammalian post …

Autophagy is a cellular catabolic process that relies on the cooperation of autophagosomes
and lysosomes. During starvation, the cell expands both compartments to enhance …

Post-translational modifications (PTMs) broadly contribute to the recent explosion of
proteomic data and possess a complexity surpassing that of protein design. PTMs are the …

Cell surface proteins are major targets of biomedical research due to their utility as cellular
markers and their extracellular accessibility for pharmacological intervention. However …

Cellular function can be controlled through the gene expression program, but often protein
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …

Lysine acetylation is a reversible posttranslational modification of proteins and plays a key
role in regulating gene expression. Technological limitations have so far prevented a global …