Keloids: a review of therapeutic management

SF Ekstein, SP Wyles, SL Moran… - International journal of …, 2021‏ - Wiley Online Library
Keloid scar formation arises from a disorganized fibroproliferative collagen response that
extends beyond the original wound margins because of excessive production of …

Pharmacotherapy for keloids and hypertrophic scars

T Murakami, S Shigeki - International Journal of Molecular Sciences, 2024‏ - mdpi.com
Keloids (KD) and hypertrophic scars (HTS), which are quite raised and pigmented and have
increased vascularization and cellularity, are formed due to the impaired healing process of …

Evidence-based management of keloids and hypertrophic scars in dermatology

EY Kim, A Hussain, A Khachemoune - Archives of dermatological research, 2023‏ - Springer
While normal, controlled wound-healing results in scars that are nearly imperceptible,
hypertrophic scars (HTS) and keloids are the result of an abnormal wound-healing process …

The renin‐angiotensin system in cutaneous hypertrophic scar and keloid formation

K Hedayatyanfard, NS Haddadi, SA Ziai… - Experimental …, 2020‏ - Wiley Online Library
Hypertrophic scar and keloid are two types of fibroproliferative conditions that result from
excessive extracellular matrix production. The underlying pathological mechanism is not …

Management of hypertrophic scars in adults: a systematic review and meta‐analysis

C Choi, I Mukovozov, A Jazdarehee… - Australasian Journal …, 2022‏ - Wiley Online Library
Hypertrophic scars (HTS) are elevated scars which occur due to abnormalities in wound
healing after injury and may be associated with pain, pruritus and functional impairment …

The role of the renin‐angiotensin system in skin physiology and pathophysiology

IMS Silva, KB Assersen, NN Willadsen… - Experimental …, 2020‏ - Wiley Online Library
Since its first description around the year 2000, the local renin‐angiotensin system (RAS) in
skin has been subject of an increasing number of studies with many additions over the last …

Evidence‐based therapy in hypertrophic scars: An update of a systematic review

SP Nischwitz, K Rauch, H Luze… - Wound Repair and …, 2020‏ - Wiley Online Library
Hypertrophic scars are still a major burden for numerous patients, especially after burns.
Many treatment options are available; however, no evidence‐based treatment protocol is …

EGCG inhibits hypertrophic scar formation in a rabbit ear model

Y Song, T Wang, L Yang, J Wu, L Chen… - Journal of cosmetic …, 2023‏ - Wiley Online Library
Objective Hypertrophic scarring is a common skin fibro‐proliferative disease, but currently
there has no satisfactory drugs for anti‐scar treatments. Previous study showed that …

Efficacy of topical losartan in management of mammoplasty and abdominoplasty scars: a randomized, double-blind clinical trial

B Khodaei, M Nasimi, E Nassireslami… - Aesthetic Plastic …, 2022‏ - Springer
Background Annually, millions of people suffer from skin scars' psychological and physical
disadvantages. Pathologic scars prevention is challenging and requires develo** feasible …

Progress in the clinical treatment of keloids

W Qi, X **ao, J Tong, N Guo - Frontiers in Medicine, 2023‏ - frontiersin.org
Keloid is a pathological scar that is higher than the skin surface following skin damage. Its
lesion range often extends beyond the original damage boundary and does not naturally …