Versatile spider venom peptides and their medical and agricultural applications
Spiders have been evolving complex and diverse repertoires of peptides in their venoms
with vast pharmacological activities for more than 300 million years. Spiders use their …
with vast pharmacological activities for more than 300 million years. Spiders use their …
Friends or foes? Emerging impacts of biological toxins
Toxins are substances produced from biological sources (eg, animal, plants,
microorganisms) that have deleterious effects on a living organism. Despite the obvious …
microorganisms) that have deleterious effects on a living organism. Despite the obvious …
Structure and analysis of nanobody binding to the human ASIC1a ion channel
Y Wu, Z Chen, FJ Sigworth, CM Canessa - Elife, 2021 - elifesciences.org
ASIC1a is a proton-gated sodium channel involved in modulation of pain, fear, addiction,
and ischemia-induced neuronal injury. We report isolation and characterization of alpaca …
and ischemia-induced neuronal injury. We report isolation and characterization of alpaca …
A selective NaV1. 1 activator with potential for treatment of Dravet syndrome epilepsy
Dravet syndrome (DS) is a catastrophic epileptic encephalopathy characterised by
childhood-onset polymorphic seizures, multiple neuropsychiatric comorbidities, and …
childhood-onset polymorphic seizures, multiple neuropsychiatric comorbidities, and …
The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype-and species-dependent: Importance of interactions at the channel subunit interface and …
Acid-sensing ion channels (ASICs) are primary acid sensors in the mammalian nervous
system that are activated by protons under conditions of local acidosis. They have been …
system that are activated by protons under conditions of local acidosis. They have been …
Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugs
Kissing bugs are known to produce anticoagulant venom that facilitates blood-feeding.
However, it is unknown how this saliva evolved and if the venom produced by the …
However, it is unknown how this saliva evolved and if the venom produced by the …
Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans
Venoms have evolved independently several times in Lepidoptera. Limacodidae is a family
with worldwide distribution, many of which are venomous in the larval stage, but the …
with worldwide distribution, many of which are venomous in the larval stage, but the …
Immunosuppressive, antimicrobial and insecticidal activities of inhibitor cystine knot peptides produced by teratocytes of the endoparasitoid wasp Cotesia flavipes …
Teratocytes are specialized cells released by parasitoid wasps into their hosts. They are
known for producing regulatory molecules that aid the development of immature parasitoids …
known for producing regulatory molecules that aid the development of immature parasitoids …
Prey specificity of predatory venoms
Venom represents a key adaptation of many venomous predators, allowing them to
immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms …
immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms …
Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: limacodidae)
Limacodidae is a family of lepidopteran insects comprising> 1500 species. More than half of
these species produce pain-inducing defensive venoms in the larval stage, but little is …
these species produce pain-inducing defensive venoms in the larval stage, but little is …