[HTML][HTML] The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?

AC Hesp, JA Schaub, PV Prasad, V Vallon… - Kidney international, 2020 - Elsevier
Diabetic kidney disease is the most common cause of end-stage kidney disease and poses
a major global health problem. Finding new, safe, and effective strategies to halt this disease …

Basic principles and new advances in kidney imaging

A Caroli, A Remuzzi, LO Lerman - Kidney international, 2021 - Elsevier
Over the past few years, clinical renal imaging has seen great advances, allowing
assessments of kidney structure and morphology, perfusion, function and metabolism, and …

Consensus-based technical recommendations for clinical translation of renal ASL MRI

F Nery, CE Buchanan, AA Harteveld, A Odudu… - … Resonance Materials in …, 2020 - Springer
Objectives This study aimed at develo** technical recommendations for the acquisition,
processing and analysis of renal ASL data in the human kidney at 1.5 T and 3 T field …

Acute effects of dapagliflozin on renal oxygenation and perfusion in type 1 diabetes with albuminuria: a randomised, double-blind, placebo-controlled crossover trial

JC Laursen, N Søndergaard-Heinrich… - …, 2021 - thelancet.com
Background Inhibitors of the sodium-glucose cotransporter 2 (SGLT2) slow the progression
of diabetic kidney disease, possibly by reducing the proximal tubule transport workload with …

Continuous bladder urinary oxygen tension as a new tool to monitor medullary oxygenation in the critically ill

RT Hu, YR Lankadeva, F Yanase, EA Osawa… - Critical Care, 2022 - Springer
Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue
oxygenation has been linked to its pathogenesis. Moreover, renal medullary tissue hypoxia …

Magnetic resonance imaging assessment of renal flow distribution patterns during ex vivo normothermic machine perfusion in porcine and human kidneys

R Schutter, VA Lantinga, TL Hamelink… - Transplant …, 2021 - Wiley Online Library
Acceptance criteria of deceased donor organs have gradually been extended toward
suboptimal quality, posing an urgent need for more objective pre‐transplant organ …

Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging: a prospective case control study

T Luther, P Eckerbom, E Cox, M Lipcsey, S Bülow… - Critical Care, 2022 - Springer
Background Renal hypoperfusion has been suggested to contribute to the development of
acute kidney injury (AKI) in critical COVID-19. However, limited data exist to support this. We …

Novel approaches in chronic renal failure without renal replacement therapy: a review

SL Martínez-Hernández, MH Muñoz-Ortega… - Biomedicines, 2023 - mdpi.com
Chronic kidney disease (CKD) is characterized by renal parenchymal damage leading to a
reduction in the glomerular filtration rate. The inflammatory response plays a pivotal role in …

MRI‐based quantification of whole‐organ renal metabolic rate of oxygen

RS Deshpande, MC Langham, K Susztak… - NMR in …, 2024 - Wiley Online Library
During the early stages of diabetes, kidney oxygen utilization increases. The mismatch
between oxygen demand and supply contributes to tissue hypoxia, a key driver of chronic …

GLP− 1 Promotes Cortical and Medullary Perfusion in the Human Kidney and Maintains Renal Oxygenation During NaCl Loading

B Haddock, KB Kristensen, M Tayyab… - Journal of the …, 2023 - Am Heart Assoc
Background GLP‐1 (glucagon‐like peptide‐1) receptor agonists exert beneficial long‐term
effects on cardiovascular and renal outcomes. In humans, the natriuretic effect of GLP‐1 …