Juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) is an umbrella term for arthritis of unknown origin, lasting
for> 6 weeks with onset before 16 years of age. JIA is the most common chronic …
for> 6 weeks with onset before 16 years of age. JIA is the most common chronic …
Functions and regulation of T cell-derived interleukin-10
Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy
We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …
2019 American College of Rheumatology/Arthritis Foundation guideline for the treatment of juvenile idiopathic arthritis: therapeutic approaches for non‐systemic …
S Ringold, ST Angeles‐Han… - Arthritis & …, 2019 - Wiley Online Library
Objective To develop treatment recommendations for children with juvenile idiopathic
arthritis manifesting as non‐systemic polyarthritis, sacroiliitis, or enthesitis. Methods The …
arthritis manifesting as non‐systemic polyarthritis, sacroiliitis, or enthesitis. Methods The …
Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation
B Soskic, E Cano-Gamez, DJ Smyth, K Ambridge… - Nature …, 2022 - nature.com
During activation, T cells undergo extensive gene expression changes that shape the
properties of cells to exert their effector function. Understanding the regulation of this …
properties of cells to exert their effector function. Understanding the regulation of this …
Genetic and epigenetic fine map** of causal autoimmune disease variants
Genome-wide association studies have identified loci underlying human diseases, but the
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …
Juvenile idiopathic arthritis
A Ravelli, A Martini - The Lancet, 2007 - thelancet.com
Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group
of arthritides of unknown cause, which begin before 16 years of age. This term …
of arthritides of unknown cause, which begin before 16 years of age. This term …
[HTML][HTML] The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis
Despite recent discoveries of genetic variants associated with autoimmunity and infection,
genetic control of the human immune system during homeostasis is poorly understood. We …
genetic control of the human immune system during homeostasis is poorly understood. We …
Post-transcriptional regulation of immune responses and inflammatory diseases by RNA-binding ZFP36 family proteins
S Makita, H Takatori, H Nakajima - Frontiers in immunology, 2021 - frontiersin.org
Post-transcriptional regulation is involved in the regulation of many inflammatory genes. Zinc
finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger …
finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger …
Type I interferons in the pathogenesis and treatment of autoimmune diseases
J Jiang, M Zhao, C Chang, H Wu, Q Lu - Clinical reviews in allergy & …, 2020 - Springer
Abstract Type I interferons (IFN-Is) are a very important group of cytokines that are produced
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …