Targeting autophagy using natural compounds for cancer prevention and therapy

S Deng, MK Shanmugam, AP Kumar, CT Yap, G Sethi… - Cancer, 2019 - Wiley Online Library
Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Curcumin, a component of golden spice: from bedside to bench and back

S Prasad, SC Gupta, AK Tyagi, BB Aggarwal - Biotechnology advances, 2014 - Elsevier
Although the history of the golden spice turmeric (Curcuma longa) goes back thousands of
years, it is only within the past century that we learned about the chemistry of its active …

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

S Ghosh, S Banerjee, PC Sil - Food and Chemical Toxicology, 2015 - Elsevier
The concept of using phytochemicals has ushered in a new revolution in pharmaceuticals.
Naturally occurring polyphenols (like curcumin, morin, resveratrol, etc.) have gained …

Curcumin: A naturally occurring autophagy modulator

A Shakeri, AFG Cicero, Y Panahi… - Journal of Cellular …, 2019 - Wiley Online Library
Autophagy is a self‐degradative process that plays a pivotal role in several medical
conditions associated with infection, cancer, neurodegeneration, aging, and metabolic …

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

H Gali-Muhtasib, R Hmadi, M Kareh, R Tohme… - Apoptosis, 2015 - Springer
Despite remarkable progress in the discovery and development of novel cancer
therapeutics, cancer remains the second leading cause of death in the world. For many …

Molecular mechanism of curcumin action in signaling pathways: Review of the latest research

P Liczbiński, J Michałowicz… - Phytotherapy …, 2020 - Wiley Online Library
Recently, many studies have been conducted trying to explain the molecular mechanism of
curcumin action in various pathological states of the cell and the organism. Curcumin is …

Curcumin and its derivatives as potential therapeutic agents in prostate, colon and breast cancers

Z Mbese, V Khwaza, BA Aderibigbe - Molecules, 2019 - mdpi.com
Cancer is a life-threatening disease and is the second leading cause of death around the
world. The increasing threats of drug-resistant cancers indicate that there is an urgent need …

Dietary phytochemicals in colorectal cancer prevention and treatment: A focus on the molecular mechanisms involved

S Afrin, F Giampieri, M Gasparrini… - Biotechnology …, 2020 - Elsevier
Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of
death. Unfortunately, current medical treatments are not sufficient due to lack of effective …

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

C Wang, X Zhang, Z Teng, T Zhang, Y Li - European journal of …, 2014 - Elsevier
Autophagy is a lysosomal degradation pathway, which is essential for cell survival,
proliferation, differentiation and homeostasis. It is well known that beta-amyloid (Aβ) …

Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death

K Wang, C Zhang, J Bao, X Jia, Y Liang, X Wang… - Scientific reports, 2016 - nature.com
Curcumin (CUR) and berberine (BBR) are renowned natural compounds that exhibit potent
anticancer activities through distinct molecular mechanisms. However, the anticancer …