During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting
to emphasize the hope of preservation and enhancement of cognitive function in late life? A …

It is proposed that proteins/enzymes be classified into two classes according to their
essentiality for immediate survival/reproduction and their function in long-term health: that is …

Obesity is increasing at unprecedented levels globally, and the overall impact of obesity on
the various organ systems of the body is only beginning to be fully appreciated. Because of …

The vagus nerve is a crucial component of the parasympathetic nervous system, facilitating
communication between the brain and various organs including the ears, heart, lungs …

Numerous studies have shown that microglia are capable of producing a wide range of
chemokines to promote inflammatory processes within the central nervous system (CNS) …

Abstract Some Diffusion Tensor Imaging studies have shown a loss of white matter (WM)
integrity linked to impaired cognitive function in obese individuals. However, inconsistent …

OBJECTIVE The comparative neuroprotective effects of different antidiabetes drugs have not
been characterized in randomized controlled trials. Here, we investigated the therapeutic …

Neurodegeneration of the central and enteric nervous systems is a common feature of aging
and aging-related diseases, and is accelerated in individuals with metabolic dysfunction …

Public health messaging calls for individuals to be more physically active and less
sedentary, yet these lifestyle behaviors have been historically studied independently. Both …