Antibacterial nanomaterials: mechanisms, impacts on antimicrobial resistance and design principles

M **e, M Gao, Y Yun, M Malmsten… - Angewandte Chemie …, 2023 - Wiley Online Library
Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health.
AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have …

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

M Vallet-Regí, F Schüth, D Lozano, M Colilla… - Chemical Society …, 2022 - pubs.rsc.org
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …

[HTML][HTML] Biosafety of mesoporous silica nanoparticles; towards clinical translation

A Lérida-Viso, A Estepa-Fernández… - Advanced Drug Delivery …, 2023 - Elsevier
Mesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who have
developed numerous systems for the encapsulation of a plethora of molecules, allowing the …

[HTML][HTML] Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers

TI Janjua, Y Cao, F Kleitz, M Linden, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They
have been used in many different biomedical fields including diagnosis, biosensing and …

Bioinspired nanotopographical design of drug delivery systems

JA Finbloom, C Huynh, X Huang… - Nature Reviews …, 2023 - nature.com
Effective drug delivery is important in the treatment of various biomedical conditions, ranging
from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can …

Macrophage-membrane-camouflaged nonviral gene vectors for the treatment of multidrug-resistant bacterial sepsis

H Cao, Y Gao, H Jia, L Zhang, J Liu, G Mu, H Gui… - Nano Letters, 2022 - ACS Publications
Sepsis is a life-threatening disease caused by systemic bacterial infections, with high
morbidity and mortality worldwide. As the standard treatment for sepsis, antibiotic therapy …

Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery

Z Sang, L Xu, R Ding, M Wang, X Yang, X Li… - Nature …, 2023 - nature.com
The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking
inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles …

Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma

M Yan, Q Chen, T Liu, X Li, P Pei, L Zhou… - Nature …, 2023 - nature.com
Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer
(TNBC). However, the limited tumor penetration and low cellular internalization efficiency of …

Powering mesoporous silica nanoparticles into bioactive nanoplatforms for antibacterial therapies: strategies and challenges

B Li, Y Liao, X Su, S Chen, X Wang, B Shen… - Journal of …, 2023 - Springer
Bacterial infection has been a major threat to worldwide human health, in particular with the
ever-increasing level of antimicrobial resistance. Given the complex microenvironment of …

Glutathione-Exhausting Nanoprobes for NIR-II fluorescence imaging-guided surgery and boosting Radiation Therapy Efficacy via Ferroptosis in breast Cancer

M Wei, J Bai, X Shen, K Lou, Y Gao, R Lv, P Wang… - ACS …, 2023 - ACS Publications
Breast-conserving surgery (BCS) is the standard of care for early breast cancer patients,
while the high ratio of reoperation is still a challenge due to inaccurate margin assessments …