Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research

SD Richardson, MJ Plewa, ED Wagner… - … Research/Reviews in …, 2007 - Elsevier
Disinfection by-products (DBPs) are formed when disinfectants (chlorine, ozone, chlorine
dioxide, or chloramines) react with naturally occurring organic matter, anthropogenic …

Endogenous DNA damage in humans: a review of quantitative data

R De Bont, N Van Larebeke - Mutagenesis, 2004 - academic.oup.com
DNA damage plays a major role in mutagenesis, carcinogenesis and ageing. The vast
majority of mutations in human tissues are certainly of endogenous origin. A thorough …

Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health

PJ O'Brien, AG Siraki, N Shangari - Critical reviews in toxicology, 2005 - Taylor & Francis
Aldehydes are organic compounds that are widespread in nature. They can be formed
endogenously by lipid peroxidation (LPO), carbohydrate or metabolism ascorbate …

[HTML][HTML] Glycation damage: a possible hub for major pathophysiological disorders and aging

M Fournet, F Bonté, A Desmoulière - Aging and disease, 2018 - ncbi.nlm.nih.gov
Glycation is both a physiological and pathological process which mainly affects proteins,
nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious …

Mechanistic targeting of advanced glycation end-products in age-related diseases

S Rowan, E Bejarano, A Taylor - … et Biophysica Acta (BBA)-Molecular Basis …, 2018 - Elsevier
Glycative stress, caused by the accumulation of cytotoxic and irreversibly-formed sugar-
derived advanced glycation end-products (AGEs), contributes to morbidity associated with …

Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by‐products

MJ Plewa, Y Kargalioglu, D Vankerk… - Environmental and …, 2002 - Wiley Online Library
Cytotoxicity and genotoxicity assays were used to analyze drinking water disinfection by‐
products (DBPs) in Chinese hamster ovary (CHO) AS52 cells. The DBPs were chosen …

AGEs, RAGEs and s-RAGE; friend or foe for cancer

S Ahmad, H Khan, Z Siddiqui, MY Khan… - Seminars in cancer …, 2018 - Elsevier
Impaired awareness of glycation biology in cancer initiation and progression is one of the
fundamental reasons for its meticulous investigation of the molecules involved in signalling …

Obesity: A perfect storm for carcinogenesis

BHL Harris, VM Macaulay, DA Harris… - Cancer and Metastasis …, 2022 - Springer
Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …

DNA damage induced by endogenous aldehydes: current state of knowledge

GP Voulgaridou, I Anestopoulos, R Franco… - Mutation Research …, 2011 - Elsevier
DNA damage plays a major role in various pathophysiological conditions including
carcinogenesis, aging, inflammation, diabetes and neurodegenerative diseases. Oxidative …

α‐Dicarbonyl compounds in food products: Comprehensively understanding their occurrence, analysis, and control

S Yan, L Wu, X Xue - … Reviews in Food Science and Food …, 2023 - Wiley Online Library
Abstract α‐Dicarbonyl compounds (α‐DCs) are readily produced during the heating and
storage of foods, mainly through the Maillard reaction, caramelization, lipid‐peroxidation …