Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …

Natural products and traditional medicines are of great importance. Such forms of medicine
as traditional Chinese medicine, Ayurveda, Kampo, traditional Korean medicine, and Unani …

Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Oxygen heterocycles are the second most common type of heterocycles that appear as
structural components of US Food and Drug Administration (FDA) approved …

Electron deficient, bivalent sulfur atoms have two areas of positive electrostatic potential, a
consequence of the low-lying σ* orbitals of the C–S bond that are available for interaction …

This review is an updated and expanded version of the three prior reviews that were
published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Simple Summary Cancer is one of the leading causes of death globally. Several studies,
efforts and treatment strategies have been put forth for the treatment of different types of …

Cells possess an armamentarium of DNA repair pathways to counter DNA damage and
prevent mutation. Here we use C. elegans whole genome sequencing to systematically …