More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

BACKGROUND Endometriosis, a common oestrogen-dependent inflammatory disorder in
women of reproductive age, is characterized by endometrial-like tissue outside its normal …

The proper restraint of the destructive potential of the immune system is essential for
maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their …

Atherosclerotic cardiovascular disease (ASCVD) is a chronic inflammatory disease of the
arterial walls and is characterized by the accumulation of lipoproteins that are insufficiently …

Regulatory T (Treg) cells are required to control immune responses and maintain
homeostasis, but are a significant barrier to antitumour immunity. Conversely, Treg …

Regulatory T (Treg) cells and T helper type 17 (Th17) cells play important roles in adaptive
immune responses, antagonizing each other in immune disorders. Th17/Treg balance is …

Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing
autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which …

Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …

The tumor microenvironment (TME) enhances regulatory T (Treg) cell stability and
immunosuppressive functions through up-regulation of lineage transcription factor Foxp3, a …

A growing amount of evidence suggests that ubiquitination and deubiquitination of
programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the …