Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …

Cell-substrate interactions play a crucial role in the design of better biomaterials and
integration of implants with the tissues. Adhesion is the binding process of the cells to the …

Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

As materials technology and the field of biomedical engineering advances, the role of
cellular mechanisms, in particular adhesive interactions with implantable devices, becomes …

Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …

Adult stem cell research has been advanced in recent years because of the cells' attractive
abilities of self-renewal and differentiation. Topography of materials is one of the key …

Electrospinning has recently gained much interest due to its ability to form scaffolds that
mimic the nanofibrous nature of the extracellular matrix, such as the size and depth …

The area of implant osseointegration is of major importance, given the predicted significant
rise in the number of orthopaedic procedures and an increasingly ageing population …

The need to control the adhesion of cells to material surfaces plays an important role in
determining the design of biomaterial substrates for biotechnology and tissue-engineering …