Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: theme and variations

CP Chan, DY ** - Rna, 2022 - rnajournal.cshlp.org
Sensing of pathogen-associated molecular patterns including viral RNA by innate immunity
represents the first line of defense against viral infection. In addition to RIG-I-like receptors …

Understanding immune responses to Lassa virus infection and to its candidate vaccines

H Murphy, H Ly - Vaccines, 2022 - mdpi.com
Lassa fever (LF) is a deadly viral hemorrhagic fever disease that is endemic in several
countries in West Africa. It is caused by Lassa virus (LASV), which has been estimated to be …

Effect of a loss of the mda5/ifih1 gene on the antiviral resistance in a Chinook salmon Oncorhynchus tshawytscha cell line

C Collins, L Chaumont, M Peruzzi, N Jamak… - PLoS …, 2024 - journals.plos.org
Cells are equipped with intracellular RIG-like Receptors (RLRs) detecting double stranded
(ds) RNA, a molecule with Pathogen-Associated Molecular Pattern (PAMPs) generated …

Immunogenicity and protective efficacy of A recombinant pichinde viral-vectored vaccine expressing influenza virus hemagglutinin antigen in pigs

S Kumari, J Chaudhari, Q Huang, P Gauger… - Vaccines, 2022 - mdpi.com
Influenza A virus of swine (IAV-S) is an economically important swine pathogen. The IAV-S
hemagglutinin (HA) surface protein is the main target for vaccine development. In this study …

IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly (I: C) in Murine Macrophages

I Aparici-Herraiz, G Sánchez-Sánchez, C Batlle… - Journal of Innate …, 2023 - karger.com
Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after
the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced …

TRIM38 Induced in Respiratory Syncytial Virus-infected Cells Downregulates Type I Interferon Expression by Competing with TRIM25 to Bind RIG-I

Q Sun, X Han, L Meng, H Li, Y Chen, L Yin, C Wang… - Inflammation, 2024 - Springer
Innate immune response is the first line of defense for the host against virus invasion. One
important response is the synthesis and secretion of type I interferon (IFN-I) in the virus …

IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly (I: C) in Murine Macrophages

IAHG Sánchez-Sánchez, CBP Rehues… - 2022 - karger.com
Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after
the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced …

Evaluation of Protective Efficacy of Viral Vector Based Swine Influenza Vaccine and a Method for B Cell Culture for Monoclonal Antibody Generation

S Kumari - 2022 - digitalcommons.unl.edu
Influenza A virus of the swine (IAV-S) is an economically important swine pathogen that has
the potential to spread to humans, thus posing an ongoing public health concern due to its …

[CITACE][C] Understanding Immune Responses to Lassa Virus Infection and to Its Candidate Vaccines. Vaccines 2022, 10, 1668

H Murphy, H Ly - 2022 - europepmc.org
Lassa fever (LF) is a deadly viral hemorrhagic fever disease that is endemic in several
countries in West Africa. It is caused by Lassa virus (LASV), which has been estimated to be …