Anticancer potential of coumarin and its derivatives

N Bhattarai, AA Kumbhar, YR Pokharel… - Mini Reviews in …, 2021 - ingentaconnect.com
Coumarins are found in higher plants like Rutaceae and Umbelliferae and essential oils of
cinnamon bark, cassia leaf, and lavender oil. Coumarin compounds show different …

Sustainable production of natural phenolics for functional food applications

R Mark, X Lyu, JJL Lee, R Parra-Saldívar… - Journal of Functional …, 2019 - Elsevier
Phenolics are a class of plant-derived natural secondary metabolites with good anticancer,
anti-inflammatory, antimicrobial and antioxidant activities. In addition to being natural health …

Choose Your Own Adventure: A Comprehensive Database of Reactions Catalyzed by Cytochrome P450 BM3 Variants

DJ Fansher, JN Besna, A Fendri, JN Pelletier - ACS catalysis, 2024 - ACS Publications
Cytochrome P450 BM3 monooxygenase is the topic of extensive research as many
researchers have evolved this enzyme to generate a variety of products. However, the …

Recent advances in the metabolic engineering of yeasts for ginsenoside biosynthesis

LL Chu, JAV Montecillo, H Bae - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Ginsenosides are a group of glycosylated triterpenes isolated from Panax species.
Ginsenosides are promising candidates for the prevention and treatment of cancer as well …

Synthesis of coumarin and homoisoflavonoid derivatives and analogs: The search for new antifungal agents

AR Ferreira, DN Alves, RD de Castro, Y Perez-Castillo… - Pharmaceuticals, 2022 - mdpi.com
A set of twenty-four synthetic derivatives, with coumarin and homoisoflavonoid cores and
structural analogs, were submitted for evaluation of antifungal activity against various …

RadH: a versatile halogenase for integration into synthetic pathways

BRK Menon, E Brandenburger… - Angewandte Chemie …, 2017 - Wiley Online Library
Flavin‐dependent halogenases are useful enzymes for providing halogenated molecules
with improved biological activity, or intermediates for synthetic derivatization. We …

Umbelliferone alleviates lipopolysaccharide-induced inflammatory responses in acute lung injury by down-regulating TLR4/MyD88/NF-κB signaling

D Wang, X Wang, W Tong, Y Cui, X Li, H Sun - Inflammation, 2019 - Springer
This study investigated the protective effect and underlying mechanism of action of
umbelliferone (Umb) against lipopolysaccharide (LPS)-induced acute lung injury (ALI). An …

A promiscuous bacterial P450: The unparalleled diversity of BM3 in pharmaceutical metabolism

S Thistlethwaite, LN Jeffreys, HM Girvan… - International Journal of …, 2021 - mdpi.com
CYP102A1 (BM3) is a catalytically self-sufficient flavocytochrome fusion protein isolated
from Bacillus megaterium, which displays similar metabolic capabilities to many drug …

Elucidation of the biosynthesis pathway and heterologous construction of a sustainable route for producing umbelliferone

Y Zhao, X Jian, J Wu, W Huang, C Huang, J Luo… - Journal of Biological …, 2019 - Springer
Background Coumarins play roles in many biological processes. Angelica decursiva is one
of the major sources of coumarins in China. Due to increasing demand for coumarins in the …

Streptomyces spp. in the biocatalysis toolbox

J Spasic, M Mandic, L Djokic… - Applied microbiology and …, 2018 - Springer
Abstract About 20,100 research publications dated 2000–2017 were recovered searching
the PubMed and Web of Science databases for Streptomyces, which are the richest known …