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Current advances in 3D dynamic cell culture systems
The traditional two-dimensional (2D) cell culture methods have a long history of mimicking in
vivo cell growth. However, these methods cannot fully represent physiological conditions …
vivo cell growth. However, these methods cannot fully represent physiological conditions …
Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …
Maintaining bovine satellite cells stemness through p38 pathway
S Ding, GNM Swennen, T Messmer, M Gagliardi… - Scientific reports, 2018 - nature.com
Isolating and maintaining the appropriate stem cell for large scale cell culture is essential in
tissue engineering or food production. For bovine satellite cells an optimized isolation and …
tissue engineering or food production. For bovine satellite cells an optimized isolation and …
Attachment and detachment strategies in microcarrier-based cell culture technology: A comprehensive review
Achieving a high cell density of animal cells is a prerequisite for different medical
applications such as cell therapy, tissue engineering, and vaccine production. Microcarrier …
applications such as cell therapy, tissue engineering, and vaccine production. Microcarrier …
High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling
F Manstein, K Ullmann, C Kropp… - Stem cells …, 2021 - academic.oup.com
To harness the full potential of human pluripotent stem cells (hPSCs) we combined
instrumented stirred tank bioreactor (STBR) technology with the power of in silico process …
instrumented stirred tank bioreactor (STBR) technology with the power of in silico process …
Efficient large-scale 2D culture system for human induced pluripotent stem cells and differentiated cardiomyocytes
Cardiac regenerative therapies utilizing human induced pluripotent stem cells (hiPSCs) are
hampered by ineffective large-scale culture. hiPSCs were cultured in multilayer culture …
hampered by ineffective large-scale culture. hiPSCs were cultured in multilayer culture …
[HTML][HTML] Bioengineering outlook on cultivated meat production
Cultured meat (also referred to as cultivated meat or cell-based meat)—CM—is fabricated
through the process of cellular agriculture (CA), which entails application of bioengineering …
through the process of cellular agriculture (CA), which entails application of bioengineering …
Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors
BS Borys, T Dang, T So, L Rohani, T Revay… - Stem Cell Research & …, 2021 - Springer
Background Human induced pluripotent stem cells (hiPSCs) hold enormous promise in
accelerating breakthroughs in understanding human development, drug screening, disease …
accelerating breakthroughs in understanding human development, drug screening, disease …
Cell-culture process optimization via model-based predictions of metabolism and protein glycosylation
In order to meet the rising demand for biologics and become competitive on the develo**
biosimilar market, there is a need for process intensification of biomanufacturing processes …
biosimilar market, there is a need for process intensification of biomanufacturing processes …
Biological considerations in scaling up therapeutic cell manufacturing
Cell therapeutics—using cells as living drugs—have made advances in many areas of
medicine. One of the most clinically studied cell-based therapy products is mesenchymal …
medicine. One of the most clinically studied cell-based therapy products is mesenchymal …