Epidemiological studies have consistently demonstrated the benefits of dietary fibre on
gastrointestinal health through consumption of unrefined whole foods, such as wholegrains …

There is now an abundance of evidence to show that short-chain fatty acids (SCFAs) play an
important role in the maintenance of health and the development of disease. SCFAs are a …

A mounting body of evidence indicates that dietary fiber (DF) metabolites produced by
commensal bacteria play essential roles in balancing the immune system. DF, considered …

The immune system responds to pathogens by a variety of pattern recognition molecules
such as the Toll-like receptors (TLRs), which promote recognition of dangerous foreign …

The different compartments of the gastrointestinal tract are inhabited by populations of micro-
organisms. By far the most important predominant populations are in the colon where a true …

The short chain fatty acids (SCFAs) acetate (C2), propionate (C3) and butyrate (C4) are the
main metabolic products of anaerobic bacteria fermentation in the intestine. In addition to …

The colonic microbiota plays an important role in human digestive physiology and makes a
significant contribution to homeostasis in the large bowel. The microbiome probably …

Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …

T cells are central players in the regulation of adaptive immunity and immune tolerance. In
the periphery, T cell differentiation for maturation and effector function is regulated by a …

Gut dysbiosis and bile acid (BA) metabolism disturbance are involved in the pathogenesis of
ulcerative colitis. This study aimed to investigate the effect of fucoidan on BA metabolism …