Bone remodelling is performed by basic multicellular units (BMUs) that resorb and
subsequently form discrete packets of bone tissue. Normally, the resorption and formation …

Bone is a highly dynamic organ that changes with the daily circadian rhythm. During the day,
bone resorption is suppressed due to eating, while it increases at night. This circadian …

Abstract Basic Multicellular Units (BMUs) conduct bone remodeling, a critical process of
tissue turnover which, if imbalanced, can lead to disease, including osteoporosis …

We propose a multiscale mechanobiological model of bone remodelling to investigate the
site-specific evolution of bone volume fraction across the midshaft of a femur. The model …

The growth of several biological tissues is known to be controlled in part by local
geometrical features, such as the curvature of the tissue interface. This control leads to …

The formation of new bone involves both the deposition of bone matrix, and the formation of
a network of cells embedded within the bone matrix, called osteocytes. Osteocytes derive …

Age‐related bone loss and postmenopausal osteoporosis are due to a dysregulation of
bone remodelling in which less bone is reformed than resorbed. This dysregulation of bone …

Tissue geometry is an important influence on the evolution of many biological tissues. The
local curvature of an evolving tissue induces tissue crowding or spreading, which leads to …

The geometric control of bone tissue growth plays a significant role in bone remodelling, age-
related bone loss, and tissue engineering. However, how exactly geometry influences the …

Human cortical bone has a complex hierarchical structure that is periodically remodelled
throughout a lifetime. This microstructure dictates the mechanical response of the tissue …