In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

Nerve globins are present in nonvertebrates and vertebrates, the first nerve globin having
been recognized in the nerve cord of the polychaete annelid Aphrodite aculeata in 1872 …

Background Neuroblastoma is a relatively common and highly belligerent childhood tumor
with poor prognosis by current therapeutic approaches. A novel anti-cancer agent of the di-2 …

Hydrogen sulfide is a critical signaling molecule, but high concentrations cause cellular
toxicity. A four-enzyme pathway in the mitochondrion detoxifies H 2 S by converting it to …

Natural selection often promotes evolutionary innovation by coopting preexisting genes for
new functions, and this process may be greatly facilitated by gene duplication. Here we …

Although discovered in 2000, neuroglobin (Ngb) functions are still uncertain. A contribution
to the role played by Ngb in neurons could certainly derive from the identification of Ngb …

Neuroglobin (Ngb), the third member of the globin family, was discovered in human and
murine brains in 2000. This monomeric globin is structurally similar to myoglobin (Mb) and …

Cytoglobin (Cygb) is a hexa-coordinated hemoprotein with yet to be defined physiological
functions. The iron coordination and spin state of the Cygb heme group are sensitive to …

Neuroglobin (Ngb) is an evolutionary conserved member of the globin family with a primary
expression in neurons of which the exact functions remain elusive. A plethora of in vivo and …

After its discovery in 2000, the notion grew that neuroglobin, a neuronal specific heme
protein, is involved in cytoprotection. To date, neuroglobin levels have been positively …