Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

The complement system of innate immunity is important in regulating humoral immunity
largely through the complement receptor CR2, which forms a coreceptor on B cells during …

Complement in mammalian plasma recognizes pathogenic, immunogenic and apoptotic cell
surfaces, promotes inflammatory responses and marks particles for cell lysis, phagocytosis …

The complement system plays crucial roles in a wide breadth of immune and inflammatory
processes and is frequently cited as an etiological or aggravating factor in many human …

Epstein-Barr virus (EBV) infection of B cells is associated with lymphoma and other human
cancers. EBV infection is initiated by the binding of the viral envelope glycoprotein (gp350) …

The interaction of complement receptor 2 (CR2)—which is present on B cells and follicular
dendritic cells—with its antigen-bound ligand C3d results in an enhanced antibody …

Human complement receptor type 2 (CR2/CD21) is a B lymphocyte membrane glycoprotein
that plays a central role in the immune responses to foreign Ags as well as the development …

In previous studies, we showed that the pathogenic fungus Cryptococcus neoformans (Cn)
produces a specific and unique protein called antiphagocytic protein 1 (App1), which inhibits …

C3 is a central protein of the complement system, which is important to immune defense and
provides a link between innate and adaptive immunity. Three pathways of complement …