Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with
the malignancy of various cancers. Signal transduction and activation of ZEB1 play …

Objectives Single-cell level analysis of articular cartilage and meniscus tissues from human
healthy and osteoarthritis (OA) knees. Methods Single-cell RNA sequencing (scRNA-seq) …

TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …

The green beet (Beta vulgaris var. cicla L.) and red beetroot (B. vulgaris var. rubra L.)
contain phytochemicals that have beneficial effects on human health. Specifically, the green …

Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …

Drug induced resistance is a widespread problem in the clinical management of cancer.
Cancer cells, when exposed to cytotoxic drugs, can reprogram their cellular machinery and …

Accumulation of lipid-laden macrophages within the arterial neointima is a critical step in
atherosclerotic plaque formation. Here, we show that reduced levels of the cellular plasticity …

Lung adenocarcinoma (LUAD) is the main component of non-small-cell lung cancer
(NSCLC) and causes a great health concern globally. The top priority of LUAD treatment is …

Despite being in the same pathway, mutations of KRAS and BRAF in colorectal carcinomas
(CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal …