If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …

All viable bacterial cells, whether they divide symmetrically or asymmetrically, must
coordinate their growth, division, cell volume and shape with the inheritance of the genome …

Gepotidacin is a first-in-class triazaacenaphthylene novel bacterial topoisomerase inhibitor
(NBTI). The compound has successfully completed phase II trials for the treatment of acute …

Structural maintenance of chromosomes (SMC) complexes organize chromosomes
ubiquitously, thereby contributing to their faithful segregation. We demonstrate that under …

DNA and RNA polymerases clash along the genome as they compete for the same DNA
template. Cells have evolved specialized strategies to prevent and resolve replication and …

In dividing cells, chromosome duplication once per generation must be coordinated with
faithful segregation of newly replicated chromosomes and with cell growth and division …

The Escherichia coli SMC complex, MukBEF, forms clusters of molecules that interact with
the decatenase topisomerase IV and which are normally associated with the chromosome …

Type IIA topoisomerases catalyze a variety of different reactions: eukaryotic topoisomerase II
relaxes DNA in an ATP-dependent reaction, whereas the bacterial representatives gyrase …

Bacterial DNA gyrase introduces negative supercoils into chromosomal DNA and relaxes
positive supercoils introduced by replication and transiently by transcription. Removal of …

Chromosome replication initiates at multiple replicons and terminates when forks converge.
In E. coli, the Tus-TER complex mediates polar fork converging at the terminator region, and …