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Emerging concepts in the science of vaccine adjuvants
Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …
the immune response. Following its introduction in the 1920s, alum remained the only …
The germinal centre B cell response to SARS-CoV-2
The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …
cells and memory B cells capable of mediating long-term protective immunity …
[HTML][HTML] Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
Vaccines generate high-affinity antibodies by recruiting antigen-specific B cells to germinal
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults
Influenza vaccines could be improved by platforms inducing cross-reactive immunity.
Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines …
Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines …
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans
Vaccine adjuvants increase the breadth of serum antibody responses, but whether this is
due to the generation of antigen-specific B cell clones with distinct specificities or the …
due to the generation of antigen-specific B cell clones with distinct specificities or the …
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants that evade immunity elicited by vaccination has placed an imperative on the …
variants that evade immunity elicited by vaccination has placed an imperative on the …
Evolution of antibody immunity following Omicron BA. 1 breakthrough infection
Understanding the longitudinal dynamics of antibody immunity following heterologous SAR-
CoV-2 breakthrough infection will inform the development of next-generation vaccines …
CoV-2 breakthrough infection will inform the development of next-generation vaccines …
“World in motion”–emulsion adjuvants rising to meet the pandemic challenges
Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as
key components of licensed vaccines, with over 100 million doses administered to diverse …
key components of licensed vaccines, with over 100 million doses administered to diverse …
[HTML][HTML] The continued advance of vaccine adjuvants–'we can work it out'
In the last decade there have been some significant advances in vaccine adjuvants,
particularly in relation to their inclusion in licensed products. This was proceeded by several …
particularly in relation to their inclusion in licensed products. This was proceeded by several …
[HTML][HTML] Resolving adjuvant mode of action to enhance vaccine efficacy
Highlights•Adjuvants can be incorporated into vaccines to enhance the magnitude,
functionality, breadth and durability of antigen-specific immune responses.•A deeper …
functionality, breadth and durability of antigen-specific immune responses.•A deeper …