There are two major clinical subsets of scleroderma:(i) systemic sclerosis (SSc) is a complex
systemic autoimmune disorder characterized by inflammation, vasculopathy, and excessive …

Systemic sclerosis remains a challenging disease despite progress that has taken place in
the management of organbased complications. Overall management strategies need to take …

Objectives. To assess the safety and efficacy of long-term treatment with rituximab (RTX) in
patients with systemic sclerosis (SSc). Methods. Eight patients with SSc-associated …

Current therapeutic modalities for the treatment of systemic sclerosis (SSc) have significant
limitations. The window of opportunity to prevent tissue fibrosis and irreversible damage …

Objective To examine the validity of a durometer to objectively measure skin hardness in
systemic sclerosis (SSc), and to compare digital durometry with the modified Rodnan skin …

Tetracycline antibiotics (TCs) have been widely employed to treat bacterial infections and
other pathologic conditions in humans and pets. Although most of TCs have been almost …

Objective To examine the range and responsiveness to change of clinical outcome
measures and study predictors of clinical response in patients with diffuse cutaneous …

Several effective drugs have been identified for the treatment of systemic sclerosis (SS c).
However, in advanced cases, not only their effectiveness is reduced but they may be also …

Substantial progress has been made in the past 10 years in the development and validation
of outcome measures and refinement of trial methodology for systemic sclerosis …

Without doubt, animal models have provided significant insights into our understanding of
the rheumatological diseases; however, no model has accurately replicated all aspects of …