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[HTML][HTML] Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease
Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …
[HTML][HTML] Human protein tyrosine phosphatase 1B (PTP1B): from structure to clinical inhibitor perspectives
Phosphorylation is an essential process in biological events and is considered critical for
biological functions. In tissues, protein phosphorylation mainly occurs on tyrosine (Tyr) …
biological functions. In tissues, protein phosphorylation mainly occurs on tyrosine (Tyr) …
Fructose and hepatic insulin resistance
Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk
factor for development of obesity and its complications, such as fatty liver disease and …
factor for development of obesity and its complications, such as fatty liver disease and …
Update on GLUT4 vesicle traffic: a cornerstone of insulin action
Glucose transport is rate limiting for dietary glucose utilization by muscle and fat. The
glucose transporter GLUT4 is dynamically sorted and retained intracellularly and …
glucose transporter GLUT4 is dynamically sorted and retained intracellularly and …
The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications
Insulin resistance, the most important characteristic of the type 2 diabetes mellitus (T2DM), is
mostly caused by impairment in the insulin receptor (IR) signal transduction pathway …
mostly caused by impairment in the insulin receptor (IR) signal transduction pathway …
Coumarins as potential antidiabetic agents
Objectives Even with great advances in modern medicine and therapeutic agent
development, the search for effective antidiabetic drugs remains challenging. Coumarins are …
development, the search for effective antidiabetic drugs remains challenging. Coumarins are …
Turn and face the strange: § a new view on phosphatases
Phosphorylation as a post-translational modification is critical for cellular homeostasis.
Kinases and phosphatases regulate phosphorylation levels by adding or removing …
Kinases and phosphatases regulate phosphorylation levels by adding or removing …
[HTML][HTML] Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders
Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered
a direct negative regulator of several receptor and receptor-associated tyrosine kinases …
a direct negative regulator of several receptor and receptor-associated tyrosine kinases …
Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders
The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …
Connecting Alzheimer's disease to diabetes: underlying mechanisms and potential therapeutic targets
Alzheimer's disease (AD) is a risk factor for type 2 diabetes and vice versa, and a growing
body of evidence indicates that these diseases are connected both at epidemiological …
body of evidence indicates that these diseases are connected both at epidemiological …