Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood
cells with one or more somatic mutations. Individuals with CH are at greater risk for …

Myelodysplastic syndrome (MDS) is a clonal disease that arises from the expansion of
mutated haematopoietic stem cells. In a spectrum of myeloid disorders ranging from clonal …

The growth and survival of cells within tissues can be affected by 'cell competition'between
different cell clones. This phenomenon was initially recognized between wild-type cells and …

Apoptotic cell death is widely considered a positive process that both prevents and treats
cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also …

Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Background Therapy-related myeloid neoplasms are secondary malignancies that are often
fatal, but their risk factors are not well understood. Evidence suggests that individuals with …

Programmed cell death (PCD) plays a fundamental role in animal development and tissue
homeostasis. Abnormal regulation of this process is associated with a wide variety of human …

Apoptosis has been established as a mechanism of anti-cancer defense. Members of the
BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found …

Therapy-related acute myeloid leukaemia (t-AML) and therapy-related myelodysplastic
syndrome (t-MDS) are well-recognized complications of cytotoxic chemotherapy and/or …