Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility
Many human phenotypes are impossible to recapitulate in model organisms or immortalized
human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease …
human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease …
Genetics and genomics of pulmonary fibrosis: charting the molecular landscape and sha** precision medicine
Recent genetic and genomic advancements have elucidated the complex etiology of
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …
[HTML][HTML] Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice
Durable reconstitution of the distal lung epithelium with pluripotent stem cell (PSC)
derivatives, if realized, would represent a promising therapy for diseases that result from …
derivatives, if realized, would represent a promising therapy for diseases that result from …
Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo
JA Torchia, AH Tavares, LS Carstensen, DY Chen… - Science …, 2022 - science.org
As severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) evolves to escape
natural antibodies, it also loses sensitivity to therapeutic antibody drugs. By contrast …
natural antibodies, it also loses sensitivity to therapeutic antibody drugs. By contrast …
[HTML][HTML] Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells
Dysfunction of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung
alveoli, is implicated in pulmonary disease pathogenesis, highlighting the importance of …
alveoli, is implicated in pulmonary disease pathogenesis, highlighting the importance of …
Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease of unknown
etiology with limited treatment options. It is characterized by repetitive injury to alveolar …
etiology with limited treatment options. It is characterized by repetitive injury to alveolar …
Metabolic reprogramming of pulmonary fibrosis
J Li, X Zhai, X Sun, S Cao, Q Yuan… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …
Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies
K Giusto, H Wanczyk, T Jensen… - Disease Models & …, 2021 - journals.biologists.com
Bronchopulmonary dysplasia (BPD) is a chronic lung disease caused by exposure to high
levels of oxygen (hyperoxia) and is the most common complication that affects preterm …
levels of oxygen (hyperoxia) and is the most common complication that affects preterm …
[HTML][HTML] Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium
Type 2 alveolar epithelial cells (AT2s), facultative progenitor cells of the lung alveolus, play a
vital role in the biology of the distal lung. In vitro model systems that incorporate human cells …
vital role in the biology of the distal lung. In vitro model systems that incorporate human cells …
Senescence of alveolar epithelial progenitor cells: A critical driver of lung fibrosis
Pulmonary fibrosis comprises a range of chronic interstitial lung diseases (ILDs) that impose
a significant burden on patients and public health. Among these, idiopathic pulmonary …
a significant burden on patients and public health. Among these, idiopathic pulmonary …