Experimental studies investigating the effects of endocrine disruptors frequently identify
potential unconventional dose-response relationships called non-monotonic dose-response …

G protein-coupled receptors (GPCRs) are seven transmembrane proteins that form the
largest single family of integral membrane receptors. GPCRs transduce information provided …

G protein–coupled receptor kinases (GRKs) constitute a family of six mammalian
serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein …

Selective PCR amplification of human and mouse genomic DNAs with oligonucleotides
encoding highly conserved regions of the δ-opioid and somatostatin receptors generated a …

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical
engineering and cell biology by lucidly and practically demonstrating how a mathematical …

β-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G
protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by …

In the case of the cannabinoid receptor, the lack of potent antagonists has been a limiting
factor in defining cannabinoid receptor-mediated responses. Several lines of evidence …

▪ Abstract G protein–coupled receptors (GPRs) play a key role in controlling hormonal
regulation of numerous second-messenger pathways. However, following agonist activation …

BACKGROUND In chronic heart failure, the positive inotropic effects of beta-adrenergic
receptor agonists are greatly reduced, in part as a result of two alterations of the cardiac beta …

Cellular responses to many hormones and neurotransmitters wane rapidly despite
continuous exposure of cells to these stimuli. This phenomenon, termed desensitization, has …